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Any drug will cumulate in the body if level of administration is much more than the rate of elimination. However, gradually eliminated drugs are significantly liable to trigger cumulative toxicity, e.g. prolonged utilization of chloroquine brings about retinal harm.Cross tolerance It truly is the event of tolerance to pharmacologically linked drugs
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10Analysis of c-di-GMP amounts employing a distinct reverse-section column and/or HPLC technique may possibly call for optimization of HPLC separation gradients.An HPLC instrument has 4 major parts: a pump to provide the mobile phase, an autosampler to inject the sample, a stationary phase column to different the sample compounds, and a detector to
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